nature12575-s1
SUPPLEMENTARY INFORMATION
a.Phosphoketolasedoi:10.1038/nature12575
or
b. Carbon rearrangement involving SBP
Figure S1. Detailed Structure of Non-Oxidative Glycolysis (NOG). a) The phosphoketolase can either react directly with F6P or X5P. In the latter case, F6P input is first converted to X5P via transketolase. b) An example of carbon rearrangement networks involving SBP. The carbon color scheme illustrates carbon rearrangement. Hydroxyl groups are not shown. The red arrows indicate irreversible reactions. Metabolite abbreviations: D-sedoheptulose 7-phosphate (S7P), D-sedoheptulose 1,7-bisphosphate (SBP), D-fructose 6-phosphate (F6P), fructose 1,6-bisphosphate (FBP), D-xylulose 5-phosphate (X5P), D-ribose 5-phosphate (R5P), D-ribulose 5-phosphate (Ru5P), D-erythrose 4-phosphate (E4P), D-glyceraldehyde 3-phosphate (G3P), dihydroxyacetone phosphate (DHAP), acetyl-phosphate (AcP). Enzyme abbreviations are 1a:F6P phosphoketolase (Fpk), 1b: X5P phosphoketolase (Xpk), 2:
transaldolase (Tal),3:Transketolase (Tkt),4:ribose-5-phosphate isomerase (Rpi),5:ribulose-5-phosphate epimerase (Rpe),6:Triose phosphate isomerase (Tpi),7:Fructose 1,6 bisphosphate aldolase (Fba),8: Fructose 1,6 bisphosphatase (Fbp), 9: Sedoheptulose-1,7-bisphosphate aldolase (Sba), 10:Sedoheptulose-bisphosphatase (Sbp).
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