第10 卷 第1 期中 华 男 科 学Vol . 10 No. 1

2004 年1 月National Journal of Andrology Jan. 2004

·综述·

孤雌生殖的胚胎干细胞研究进展

陈林君1 ,2 综述; 李红霞2 审校

(1. 南京师范大学生命科学学院, 江苏南京210097 ; 2. 南京市妇幼保健院生殖中心, 江苏南京210004)

摘要: 人类胚胎干细胞可以在体外诱导分化成为人体的各种细胞,用于医学临床和科学研究。由于胚胎干细胞来

源于胚胎,在某些国家和地区受到宗教、道德和伦理的制约。孤雌生殖的胚胎干细胞具有与胚胎干细胞相同的全

能性和增殖性,可以在体外诱导分化成为体内的各种细胞。本文就孤雌生殖的胚胎干细胞的体外建系、定向分化

的研究进展作一综述。

关键词: 孤雌生殖; 胚胎干细胞;

中图分类号: Q132 ; R329. 1 文献标识码: A 文章编号: 100923591 (2004)

0120055204

Progress in the Studies of Parthenogenetic Embryonic Stem Cells

Chen Linjun , Li Hongxia

Life Science College of Nanjing Normal University , Nanjing , Jiangsu 210097 , China ( Chen LJ ) ; IVF Center of Nanjing

Maternity & Children Health Hospital , Nanjing , Jiangsu 210004 , China ( Li HX) Correspondence to : Li Hongxia

Abstract : Human embryonic stem cells can be induced to differentiate into all kinds of cells in vitro to be applied to clinical medicine and sci2

entific research. Because they have to be isolated from human embryos , any attempt to establish human stem cell line is prohibited by religion

and ethics in some areas and countries. Parthenogenetic embryonic stem cells have similar capacity of totipotency and proliferation , and can be

established from parthenogenetic activation of discarded oocytes. This paper reviews the progress in the studies of the establishment of partheno2

genetic embryonic stem cell line and its differentiation capacities. Natl J Androl , 2004 , 10 ( 1) : 55258

Key words : parthenogenesis ; embryonic stem cell

孤雌生殖是指在没有精子参与的情况下,卵细

胞能发育为一个胚胎的过程。即无雄性配子的任何